1.
Acta Pharmaceutica Sinica
;
(12): 735-41, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-382477
ABSTRACT
To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, twelve target compounds were synthesized, and their structures were confirmed by 1H NMR, MS and elemental analyses. Evaluation results in vitro showed that compound Ia exhibited potent inhibition against HDAC and is worth for further investigation. And compounds IIa, IIb, IIIa-IIIi possessed moderate HDAC inhibitory activity.